ABSTRACT
One of the objectives of pre-surgical evaluation in mesial epilepsy associated to hippocampal sclerosis is the identification of patients with bad surgical prognosis for seizure ccontrol. At least theoretically, neuropsychological tests could be used in this venue. To evaluate whether verbal and visual memory tests can be used as isoleted predicotrs of the post-surgical sizure outcome in patients wit mesial temporal lobe epilepsy associated with hippocampal sclerosis refractory to pharmacological treatment. In a retrospective cohort study using the control of epileptic seizres as end-point, we evaluated 187 patients and calculated the correlation of clinical variables, cognitive evaluation, neuroimaging data, demographic data and electrophysiological findings with the result of seizure control after lobectomy in these patients. An unfavorable prognosis during the postoperative period was observed only in association with low visual reproduction scores (visual memory). However, afterBonferrroni corrections, which was necessary to reduce the chance of type I error this result was found to be spurious. We conclude that neuropsychological tests of verbal and visual memory such as those used in the routine presurgica evaluation of our patients with temporal lobe epilepsy are not good isolated predictors of surgical outcome